Diabetes

HSCI co-director leads multi-institutional center to advance type 1 diabetes research

February 23, 2021

The JDRF Center of Excellence in New England will accelerate beta cell replacement therapy

Harvard Stem Cell Institute (HSCI) co-director Douglas Melton, Ph.D., will lead a new multi-institutional center funded by JDRF to advance type 1 diabetes research. The JDRF Center of Excellence in New England will focus on the transplantation of beta cells, the insulin-producing cells of the pancreas that are attacked by the immune system during type 1 diabetes.

The center is also led by JDRF scientific staff leader Esther Latres, Ph.D. Other collaborators include...

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Cell therapy for all

November 1, 2018

Chad Cowan is on a quest for the universal donor, which would make cell therapy available to populations – not just individuals.

  • Harvard scientist Chad Cowan aims to make off-the-shelf cellular products, and democratize access to new medicines.
  • His lab is working to make cellular therapies that can work for anyone, not just a single patient. 
  • Their ambitious goal is to modify therapeutic cells that can be transplanted into many people, without being rejected.

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How insulin-producing cells show their age

April 6, 2017

Adapted from a Joslin Diabetes Center press release

Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets. Using newly identified cellular markers of aging, Joslin Diabetes Center scientists now have shown that this diversity may be driven at least in part by differently aged beta cell populations within the pancreas. 

Additionally, the Joslin team demonstrated that the aging of beta cells, with associated losses of...

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