Aging
Why do we lose the ability to repair and regenerate over time? Why do some parts of our bodies age more slowly than others?
By comparing repair processes in young and old animals, across organ systems, HSCI researchers have identified circulating factors that can restore function to damaged tissue. These findings have sparked a new generation of cross-sector research that has implications for many conditions associated with aging.
By analyzing gene expression in tens of thousands of cells, HSCI scientists have also identified aging patterns in every cell type of the brain, such as the specialized endothelial cells that line blood vessels. The resulting knowledge base is transformative for the field of aging research, well beyond the HSCI network.