Ruth Franklin, PhD
Harvard Faculty of Arts and Sciences
Harvard Medical School
Ruth Franklin’s laboratory explores the role of the innate immune system in tissue repair and homeostasis, with a focus on the communication between macrophages and non-immune cells within tissues.
Cells of the immune system defend against a variety of insults, including infection by pathogens. However, it is now clear that immune cells also have important functions during development, tissue repair, and homeostasis. The Franklin laboratory uses mouse models of infection, fibrosis, and cancer to investigate how immune cells sense and respond to both subtle changes in the tissue environment and extreme perturbations that drive inflammation. Dr. Franklin is interested in understanding how cells of the immune system communicate with non-immune cell types within tissues, including fibroblasts and neurons, to elicit both local and systemic responses during homeostasis and disease.
Research topics in the laboratory include macrophage biology, disease tolerance, and neuro-immune interactions.