Research

HSCI research programs bridge the gaps in traditional funding to encourage bold thinking and launch scientific careers. Our collaborative environment gives rise to new ideas, new programs, and the resources to support them.

Disease programs

HSCI disease programs allow us to channel out world-class resources — both intellectual and technological — toward some of the most prevalent, devastating diseases for which stem cell research can hold promise.

The HSCI Blood Program, led by Daniel G. Tenen, M.D., aims to discover how to turn regeneration on and off. This knowledge has implications for leukemia and lymphoma, and for human diseases across the board.

The HSCI Cancer Program, led by Mario Suva, M.D., Ph.D., aims to discover how to kill stem cells — and their entire lineage — without damaging healthy cells.

The HSCI Cardiovascular Program, led by Richard Lee, M.D., aims to generate new human heart cells to replace damaged heart tissue. This has particular implications for diseases of aging, and for heart disease.

The HSCI Diabetes Program aims to cure diabetes. Led by Doug Melton, Ph.D., the program explores how to create beta cells efficiently, and protect them from attack by the immune system. This has direct implications for Type I Diabetes and Type II Diabetes.

Researchers in the HSCI Kidney Program, led by Iain Drummond, Ph.D., are dedicated to finding new treatments for patients with kidney disease. Their interests are regenerative biology in general, and fibrosis in particular.

The HSCI Nervous System Diseases Program, led by Lee Rubin, Ph.D. and Tracy Young-Pearse, Ph.D., investigates neurodegenerative and traumatic diseases of the brain and spinal cord. Their goal is to understand exactly which neurons degenerate and why, and how to interfere with the degenerative process to provide a therapy. Their research covers a broad range of disorders, including ALSAlzheimer's diseaseeye diseaseshearing lossMultiple Sclerosis, and Parkinson's disease.

The HSCI Skin Programled by Markus Frank, M.D. and George F. Murphy, M.D., aims to discover how to regenerate tissue without scarring. This research focuses on skin repair and regeneration, and has implications for many types of skin cancers.

Early-Stage Research

HSCI Seed Grants and Junior Faculty Programs
We provide early funding for innovative projects in stem cell research. This allows early-career scientists to pursue "high risk/high reward" avenues of research that might be difficult to fund from other sources.

MD/PhD Fellowship
The HSCI Medical Scientist Training Fellowship is awarded to Harvard Medical School students who demonstrate strong interest in stem cell research and HSCI believes will contribute to the future of the field.

HSCI Internship Program
HSCI's leading stem cell internship program provides undergraduate students with a focused and challenging summer research experience in a cutting-edge stem cell lab.

Core Facilities

Members of the HSCI community benefit from resources that are beyond the means of any individual lab. Our core facilities offer immediate access to specialized equipment, reagents and materials, know-how, and training.