Brown adipocytes are specialized cells that can use energy to produce heat. This property makes them attractive tools for the treatment of diseases like obesity and type 2 diabetes. Until recently, this therapeutic potential was constrained by limited understanding of how brown adipocyte tissue (BAT) develops from precursors.
A team led by investigators at Brigham and Women’s Hospital identified a set of cellular signaling cues that lead up to brown adipocyte formation in mice. They then used these cues to develop a protocol...
Jason Buenrostro and Fei Chen are leaders in the field of single-cell genomics, developing new tools to learn more about how cells with the same genome can have such varied functions.
A one-time treatment using small molecules to target progenitor cells, pioneered in the lab of a Harvard Stem Cell Institute researcher, may potentially restore hearing lost from some of the most common causes