Seed Grant Awards

HSCI Seed Grant-funded projects include:

2016 Seed Grant Recipients

Project Lead Affiliation Title  Research Area
Daniel Bauer, MD, PhD Boston Children's Hospital Targeted Disruption of the BCL11A erythroid Enhancer in Hematopoietic Stem Cells for Genetic Therapy of the beta-Hemoglobinopathies Blood Disease
Fernando Camargo, PhD Boston Children’s Hospital Small molecule manipulation of Hippo signaling for regeneration Epithelial Regeneration and Wound Healing
April Craft, PhD Boston Children's Hospital Preclinical development of engineered hPSC-derived tissues for articular cartilage repair Musculoskeletal Disease
Yick Fong, PhD Brigham and Women's Hospital Identifying mechanisms of discern ribonucleoprotein dysfunction in stem cell disorders Blood Disease
Maria Lehtinen, PhD Boston Children's Hospital A synthetic cerebrospinal fluid supplement to protect hippocampal stem cells from chemotherapy Cancer, Neurological Disease
Ryuji Morizane, MD, PhD Brigham and women's Hospital Modeling glomerular disease in vascularized kidney organoids derived from human pluripotent stem cells Kidney Disease
George Murphy, MD and Markus Frank, MD Brigham and Women's Hospital/ Boston Children’s Hospital A stem cell-based cutaneous bioprothesis Skin Disease, Skin Regeneration
Christine Seidman, MD Harvard Medical School Developing Trypanosome cruzi-infected iPSC-derived cardiomyocytes as a model for Chagas cardiomyopathy Cardiovascular Disease, Infection
Thomas Serwold, PhD Joslin Diabetes Center Factors that promote thymus regeneration Aging, Type 1 Diabetes, Autoimmunity

2015 Seed Grant Recipients

Project Lead Affiliation Title  Research Area
Carla Kim, PhD Boston Children's Hospital

Stem cell differentiation tools to reveal new targets in cystic fibrosis

Cystic Fibrosis
Amar Sahay, PhD and Rakesh Karmacharya, MD, PhD Massachusetts General Hospital

Generation and characterization of human hippocampal CA3 pyramidal neurons

Neuroscience
Mustafa Sahin, MD, PhD Boston Children's Hospital

Autistic neurons in a dish

Autism
David Williams, MD and Scott Snapper, MD, PhD Boston Children’s Hospital Hematopoietic stem cell gene therapy for very early onset Inflammatory Bowel Disease due to IL 10-receptor deficiency Inflammatory Bowel Disease
Andreas Herrlich, MD, PhD Brigham and Women's Hospital Inhibition of ADAM17-dependent pathways in kidney fibrosis Kidney Disease

2013 Seed Grant Recipients

Project Lead Affiliation Title Research Area
Reza Abdi, MD Brigham and Women’s Hospital The targeted delivery of mesenchymal Stem cells for the treatment of type 1 diabetes Diabetes
Suneet Agarwal, MD, PhD Boston Children’s Hospital Manipulating heteroplasmy in mitochondrial genetic diseases Mitochondrial Genetic Diseases
Sangmi Chung, PhD McLean Hospital Human medial ganglionic eminence cells as a potential source for novel cell-based therapy for temporal lobe epilepsy Epilepsy
Natasha Frank, MD Boston Children’s Hospital ABCB5+ limbal stem cells for LSCD therapy Eye Diseases
Jenna Galloway, PhD Massachusetts General Hospital Tendon regeneration in zebrafish Tendon and Ligament Injuries
Tatsuya Kobayashi, MD, PhD Massachusetts General Hospital Characterization and manipulation of articular cartilage chondrocytes as stem/progenitor cells Osteoarthritis
Maria Kontaridis, PhD and Amy Roberts, MD Beth Israel Deaconess Medical Center/ Boston Children’s Hospital Elucidation of the epigenetic, transcriptional, and differentiation abnormalities underlying RASopathy disorders in iPS cells Genetic Diseases
David Milan, MD Massachusetts General Hospital Novel method to map human genetic disease using induced pluripotent stem cells Genetic Diseases
Jayaraj Rajagopal, MD Massachusetts General Hospital Developing humanized mouse models of respiratory disease Respiratory Disease

2012 Seed Grants

Project Lead Affiliation Title Research Area
Susan Dymecki, MD, PhD Harvard Medical School Reverse engineering serotonin neuron subtypes Neuronal Disorders
Stephen Haggarty, PhD Massachusetts General Hospital Characterization of iPSC-derived neurons from patients with intellectual disability: role of TCF4 in Pitt-Hopkins Syndrome Neuronal Disorders
Bernhard Kuhn, MD Boston Children's Hospital Controlling the differentiation of ES and iPS-derived heart muscle cells Cardiovascular Disease
Rohit Kulkarni, MD, PhD Joslin Diabetes Center Significance of MODY genes in the differentiation of human iPS cells into insulin-secreting beta cells Diabetes
Cammie Lesser, MD, PhD Massachusetts General Hospital Non-viral transdifferentiation of fibroblasts to cardiomyocytes Cardiovascular Diseases
Michael Mannstadt, MD Massachusetts General Hospital Directed differentiation of ES and iPS cells towards parathyroid cells Endocrine Disorders
Thomas Serwold, PhD Joslin Diabetes Center Identification and functional characterization of thymic epithelial stem cells and progenitors Immunology
Matthew Steinhauser, MD Brigham and Women’s Hospital Quantifying human cell division with a heavy water tracer Cellular Imaging
Clifford Tabin, PhD Harvard Medical School Analysis of blastema cell heterogeneity by RNA-seq Tissue Regeneration & Repair
Tracy Young-Pearse, PhD Brigham and Women’s Hospital Establishment of a single cell assay to screen individual cell types for efficacy of putative small molecule drugs Single-Cell Analysis

2011 Seed Grants

Project Lead Affiliation Title Research Area
Wolfram Goessling, MD, PhD Brigham and Women's Hospital Functional characterization of genes associated with abnormal liver tests for liver development and repair – a post-GWAS approach Liver Disease
Stanley Shaw, MD, PhD Massachusetts General Hospital Small molecule inhibitors of p16INK4a: proof-of-concept for the generation of iPS cells via a high-throughput screening platform Cardiovascular Disease
Carla F. Kim, PhD Boston Children's Hospital Imprinted gene regulation in lung and skin stem cell self-renewal Cancer
Elliot Chaikof, MD, PhD Beth Israel Deaconess Medical Center Engineered fascia for stem cell therapy in hernia repair Hernia
Rakesh Karmacharya, MD, PhD McLean Hospital Identification of cellular signatures for schizophrenia in iPSC-derived neuronal cells Neuropsychiatric Diseases
Sandra McAllister, PhD Brigham and Women's Hospital Understanding how systemic factors govern breast cancer stem cell plasticity and malignancy Cancer
Chien-Wei (Eric) Liao, MD, PhD Massachusetts General Hospital Transcriptome and functional analysis of neural crest stem cell Genetic Diseases
Xu Wu, PhD Massachusetts General Hospital Controlling stem cell self-renewal and differentiation using small molecule modulators of hippo signaling pathway Cancer
Jordan A. Kreidberg, MD Boston Children's Hospital Reprogramming ES and IPS cells into kidney progenitor cells Kidney Disease
Joy Wu, MD, PhD Massachusetts General Hospital Chemical screening of pluripotent stem cells for modifiers of mesenchymal lineage commitment Osteoporosis

2010 Seed Grants

Project Lead Affiliation Title Research Area
Andrew Brack, PhD Massachusetts General Hospital The regulation and functional capacity of skeletal muscle satellite cells in dystrophic muscle Musculoskeletal Disease
C. Geoffrey Burns, PhD Massachusetts General Hospital Chemical genetic screen for modifiers of cardiac stem cell function during zebrafish embryogenesis Cardiovascular Disease
Cassandra Extavour, PhD Faculty of Arts and Sciences, Harvard University Exploring germline regeneration: a transcriptome approach to understanding transdifferentiation of somatic cells into germ cells Genetic Diseases
Richard I. Gregory, PhD Boston Children's Hospital Molecular and cellular function of a novel stem cell factor Trim71 Genetic Diseases
Craig P. Hunter, PhD Faculty of Arts and Sciences, Harvard University Control of stem cell homeostasis by the dsRNA transporter SidT2 Genetic Diseases
Akio Kobayashi, PhD Brigham and Women's Hospital Cell fate decision in nephron progenitor cells of the kidney Kidney Diseases
Andrew Lassar, PhD Harvard Medical School How FGF signals maintain phenotypic plasticity in mesenchymal stem cells Musculoskeletal Disease
Zhe Li, PhD Brigham and Women's Hospital Luminal progenitors as cells of origin for breast cancer Cancer
Jayaraj Rajagopal, MD Massachusetts General Hospital Identification of factors that direct the differentiation of ES Cells into lung endoderm progenitors using developmentally guided growth factors and chemical screening platforms Lung Disease
Judith Arunodhaya Steen, PhD Boston Children's Hospital Quantitative proteomics to reveal progenitor specific markers on the cell surface Cancer

2009 Seed Grants

Program Lead Affiliation Title Research Area
Wolfram Goessling, MD, PhD and
Trista E. North, PhD
Brigham and Women's Hospital and
Beth Israel Deaconess Medical Center
Isolating novel regulators of liver regeneration through a chemical genetic modifier screen in zebrafish Liver Disease
Mark Damone Johnson, MD, PhD Brigham and Women's Hospital Cancer stem cells in meningiomas Cancer
David M. Langenau, PhD Massachusetts General Hospital Imaging notch pathway requirements for symmetric vs. asymmetric self-renewal divisions in embryonal rhabdomyosarcoma Cancer
Sharad Ramanathan, PhD Faculty of Arts and Sciences, Harvard University Studying decision making in single embryonic stem cells Bioengineering
Derrick J. Rossi, PhD Immune Disease Institute In vivo reprogramming of lineage committed progenitor cells to hematopoietic stem cells Blood Disease
Yu Hua Tseng, PhD Joslin Diabetes Center Identification and significance of brown fat progenitor cells Diabetes
David Weinstock, MD Dana-Farber Cancer Institute DNA double-strand break repair in human pluripotent cells Cancer
Paul B. Yu, MD, PhD Massachusetts General Hospital Identification of osteogenic progenitors in heterotopic ossification Musculoskeletal Disease

2008 Seed Grants

Program Lead Affiliation Title Research Area
Paola Arlotta, PhD Harvard University Department of Stem Cell and Regenerative Biology Directed differentiation of neural progenitors and iPS Cells into corticospinal motor neurons Nervous System Disease
Sangeeta Bhatia, MD, PhD Brigham and Women's Hospital High-throughput platform for probing inductive interactions in embryonic stem cell differentiation Bioengineering
Caroline E. Burns, PhD Massachusetts General Hospital Lineage analysis of cardiac progenitor cells in vivo Cardiovascular Disease
Stephen Haggarty, PhD Massachusetts General Hospital Characterization on the Wnt/GSK-3beta pathway in fragile X syndrome using a human induced pluripotent stem cell model Genetic Diseases
Xue (Sean) Li, MD, PhD Boston Children's Hospital Renal progenitor cells: Genetic studies of Eya1 protein phosphatase Kidney Disease
Judy Lieberman, PhD Immune Disease Institute An siRNA screen for genes that regulate breast cancer stem cells Cancer
William T. Pu, MD Boston Children's Hospital Epicardial cardiac progenitors in the developing and adult heart Cardiovascular Disease
Zhong Wang, PhD Massachusetts General Hospital ATP-dependent chromatin remodeling in mouse and human ES cell pluripotency Cardiovascular Disease
Rebecca Wingert, PhD Massachusetts General Hospital Molecular networks regulating the segment fate decisions of renal progenitors Kidney Disease
Sean Wu, MD, PhD Massachusetts General Hospital Functional biology of induced pluripotent stem cell-derived organ Bioengineering

2007 Seed Grants

Project Lead Affiliation Title Research Area
Li Chai, MD Brigham and Women's Hospital SALL4 Dependent Transcriptional Network in Human and Murine Embryonic Stem Cells Cancer
Zheng-Yi Chen, PhD Massachusetts General Hospital Inner ear stem cell genes: identification, function and role in hair cell regeneration Hearing Loss
Dieter Egli, PhD Faculty of Arts and Sciences, Harvard University Derivation of patient specific human embryonic stem cell lines by chromosome transfer into human zygotes and blastomeres Genetic Diseases
Benjamin Humphreys, MD, PhD Brigham and Women's Hospital Epithelial Cell Lineage Analysis During Renal Repair Kidney Disease
Richard I. Gregory, PhD Children's Hospital Boston Promoting stem cell expansion through chemical inhibition of microRNA-mediated cell differentiation Genetic Diseases
Carla F. Kim, PhD Children's Hospital Boston Lineage tracing of lung stem cells in vivo & in vitro Lung Disease
Kameran Lashkari, MD The Schepens Eye Research Institute Application of retinal progenitor cells derived from eyes with persistent fetal vasculature to replace lost retinal ganglion cells in clinical glaucoma Eye Diseases
Stuart H. Orkin, MD Dana-Farber Cancer Institute Down Syndrome, somatic mutation of GATA-1, and acute megakaryoblastic (M7 AML) leukemia Cancer
Sridhar Rao, MD, PhD
Ibrahim Domian, MD, PhD
Dana-Farber Cancer Institute
Massachusetts General Hospital
Identification of Master Transcriptional Regulators for Early Lineage Commitment Cancer
Sabina Signoretti, MD Brigham & Women's Hospital Identification of stem cells in prostate and bladder epithelia Urinary Diseases

2006 Seed Grants

Project Lead Affiliation Title Research Area
Raymond Anchan, MD, PhD Brigham and Women's Hospital Derivation of human embryonic stem cells (hESCs) from blastomere biopsies Genetic Diseases
Scott A. Armstrong, MD, PhD Children's Hospital Boston Development of a hematopoietic stem cell and lineage differentiation map and repository Blood Diseases
Bradley Bernstein, MD PhD Massachusetts General Hospital Epigenetic mechanisms of ES cell pluripotency Genetic Diseases
Keith Blackwell, MD Joslin Diabetes Center Functions of the oocyte RNA-binding P-body protein CAR-1 Diabetes
David Breault, MD, PhD Children's Hospital Boston Characterization of Putative Intestinal Progenitor/Stem Cells using mTert-GFP Transgenic Mice Gastrointestinal Diseases
Rona Carroll, PhD Brigham and Women's Hospital Mesenchymal stem cell-based therapy for human brain tumors Cancer
Konrad Hochedlinger, PhD Harvard University Department of Stem Cell and Regenerative Biology Analysis of the pluripotency factors Oct4, Nanog and Sox2 in Adult Mice Cancer
Hanno Hock, MD, PhD Massachusetts General Hospital Deciphering the Biology of the Transcriptional Repressor Tel/Etv6 in Hematopoietic Stem Cells Blood Diseases
Charles Lin, PhD Massachusetts General Hospital In-vivo Imaging of Hemotopoietic Stem Cell Niche Blood Diseases
Anjana Rao, PhD Immune Disease Institute Identifying DNA demethylases Genetic Diseases
Rosalind Segal, MD, PhD Dana-Farber Cancer Institute Symmetric and Asymmetric Proliferation of Glioma Stem Cells Cancer
Yaming Wang, MD Brigham and Women's Hospital Evaluation of the regeneration capacity of msx1-induced dedifferentiated cells Genetic Diseases
Jing-Wei Xiong, PhD Massachusetts General Hospital The Hemangioblast Development in Zebrafish Cancer

2005 Seed Grants

Project Lead Affiliation Title Research Area
Nabeel Bardeesy, PhD Massachusetts General Hospital he pancreatic adenocarcinoma cell-of-origin Cancer
Dong Feng Chen, MD, PhD Schepens Eye Research Institute Repairing retinal disease and damage by neural stem/progenitor cell transplantation Eye Diseases
Alan James Davidson, PhD Massachusetts General Hospital Functional genomics approach to identify genes expressed in the kidney Kidney Diseases
Kevin C. Eggan, PhD Harvard University Department of Stem Cell and Regenerative Biology Derivation of Parkinson's disease specific human embryonic stem cell lines Nervous System Diseases
Niels Geijsen, PhD Massachusetts General Hospital In vitro germ cell development and epigenetic reprogramming using human and murine ES cells Genetic Diseases
Rohit Kulkarni, MD, PhD Joslin Diabetes Center Identification of beta cell growth factor Diabetes
Jeannie Lee, MD, PhD Massachusetts General Hospital Analysis of X-chromosome inactivation in human embryonic stem cells Genetic Diseases
M. William Lensch, PhD Children's Hospital Boston The analysis of complex genetic syndromes using disease-specific human embryonic stem cell lines Genetic Diseases
Craig Michelli, PhD Harvard Medical School Progenitor cells in the adult Drosophila gut: understanding tissue renewal in endoderm lineages Gastrointestinal Diseases
Hanna Mikkola, MD, PhD Dana-Farber Cancer Institute Placenta as a niche for hematopoietic stem cell development Blood Diseases
Rosario Sanchez-Pernaute, MD, PhD McLean Hospital Characterization, transplantation and functional analysis of dopamine neuronal progenitors derived from primate and human embryonic stem cells Nervous System Diseases
Amy Wagers, PhD Harvard University Department of Stem Cell and Regenerative Biology Biology and function of adult skeletal muscle precursor cells Musculoskeletal Diseases