Cancer

Targeted BMI1 inhibition impairs tumor growth lung adenocarcinomas with low CEBPα Expression

August 3, 2016

Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), in collaboration with Harvard Stem Cell Institute (HSCI), have discovered a new way in which the development of lung cancer can be stopped. In a study published in Science Translational Medicine, the researchers found that inhibiting a protein called BMI1 impaired tumour growth in lung cancer.

The study was led by HSCI Principal Faculty member Daniel Tenen, MD, his associate Elena Levantini, PhD, and included first author Dr Kol Jia Yong, a former CSI… Read more about Targeted BMI1 inhibition impairs tumor growth lung adenocarcinomas with low CEBPα Expression

Breaking leukemia's rhythm

April 7, 2016

New study shows that circadian rhythm circuitry is essential for acute myeloid leukemia stem cells but not healthy blood cells, suggesting possible pathways for therapeutics

By Veronica Meade-Kelly, the Broad Institute of MIT and Harvard

According to a… Read more about Breaking leukemia's rhythm