Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), in collaboration with Harvard Stem Cell Institute (HSCI), have discovered a new way in which the development of lung cancer can be stopped. In a study published in Science Translational Medicine, the researchers found that inhibiting a protein called BMI1 impaired tumour growth in lung cancer.
The study was led by HSCI Principal Faculty member Daniel Tenen, MD, his associate Elena Levantini, PhD, and included first author Dr Kol Jia Yong, a former
First demonstration of a cancer arising from a single cell
by Nancy Fliesler, Boston Children's Hospital
Harvard Stem Cell Institute researchers at Boston Children’s Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal. Their work, published in the
Mouse rhabdomyosarcoma tumors produced by activated muscle stem cells with high Yap activity (green; top panels) decrease in size when Yap activity is lowered (bottom panels, as shown by the green tumor cells starting to form muscle tissue and express normal muscle differentiation