Eye Diseases

Healing without scars

November 7, 2018

George Murphy wants to use stem cells to replace scarring with regenerative healing.

  • George Murphy’s goal is to coax skin stem cells into healing wounds by regenerating tissue instead of forming a scar.
  • To figure out how to do it, he is studying scarless healing during fetal development and “stem cell burnout” during aging.
  • Insights into scarless healing will help research into regenerating other vital organs, including the heart.

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Can we restore sight?

November 7, 2018

Markus Frank and his colleagues are reprogramming skin cells with the goal of giving people back their sight.

  • Seed funding from HSCI led Markus Frank and his colleagues to discover that the cell surface molecule ABCB5 can be used to identify limbal stem cells, which regenerate the cornea.
  • The team is developing ABCB5-positive cell therapy as a treatment for vision loss due to limbal stem cell deficiency.

Markus Frank, M.D., co-leader of the HSCI Skin Program, is reprogramming stem cells from the skin...

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Seeing the Light

March 25, 2015

HSCI Principal Faculty member Connie Cepko and postdoctoral researcher Wenjun Xiong talk about developing a gene therapy to stave off blindness. Video: Rick Groleau

Gene therapy slows vision loss in mouse models of retinal degeneration

By Stephanie Dutchen, Harvard Medical School Writer

Researchers have...

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