Nervous System Diseases

Paola Arlotta photo portrait

Paola Arlotta, Ph.D.

Chair, Harvard Department of Stem Cell and Regenerative Biology
Golub Family Professor of Stem Cell and Regenerative Biology, Harvard University
Associate Member, Stanley Center for Psychiatric Research, Broad Institute

Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex

The execution of critical behaviors like movement, emotion, and intelligence relies on the orchestrated integration into functional circuits of an outstanding diversity of neuronal subtypes. Focusing on excitatory pyramidal neurons of the mammalian cerebral cortex, our work aims to understand the... Read more about Paola Arlotta, Ph.D.

Harvard Department of Stem Cell and Regenerative Biology, Sherman Fairchild Building, 7 Divinity Ave., Cambridge, MA 02138
Susan Dymecki, MD, PhD

Susan Dymecki, MD, PhD

Harvard Medical School

The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification, differentiation, and migration paths taken by specific sets of cells originating from primitive neuroectoderm.... Read more about Susan Dymecki, MD, PhD

Lee Rubin headshot for profile

Lee L. Rubin, Ph.D.

Harvard Department of Stem Cell and Regenerative Biology
Principal Faculty, Harvard Stem Cell Institute


Dr. Lee Rubin, co-leader of the HSCI Nervous System Diseases Program, has a broad experience in both academia and industry, particularly in the realms of cell-based assays and drug discovery. He received his PhD in neuroscience from the Rockefeller University and had postdoctoral training, also in Neuroscience, at Harvard Medical School and Stanford University School of Medicine.... Read more about Lee L. Rubin, Ph.D.