Joslin Diabetes Center

Susan Bonner-Weir, PhD

Susan Bonner-Weir, PhD

Joslin Diabetes Center
Harvard Medical School

With a series of rodent models, Dr. Bonner-Weir has provided compelling evidence that adult pancreatic beta-cell mass increases in response to a metabolic need and her lab has been examining the mechanisms of postnatal pancreatic growth. More broadly, her lab's focus is on how the pancreatic beta cell changes with age and response to challenges.... Read more about Susan Bonner-Weir, PhD

Amy Wagers, PhD

Amy Wagers, PhD

Co-chair, Harvard Department of Stem Cell and Regenerative Biology
Senior Investigator, Islet Cell and Regenerative Biology, Joslin Diabetes Center

Stem cells are rare and unique cells capable of generating many different types of cells needed in the body. In adult tissues, different organs contain different stem cell populations, each of which produces a subset of the body's cells. For example, hematopoietic (blood-forming) stem cells generate all of the red and white blood cells needed to deliver oxygen to body tissues, fight infection, and stop bleeding. Similarly, myogenic (muscle-forming) stem cells generate mature muscle fibers necessary for controlled contraction of skeletal muscle. Work in the Wagers Lab focuses on understanding the mechanisms that regulate the function of these blood-forming and muscle-forming stem cells so that their potential can be optimally exploited for the treatment of diseases such as cancer, anemia, muscular dystrophy, and diabetes.... Read more about Amy Wagers, PhD