Rohit Kulkarni, MD, PhD
Harvard Medical School
The major focus of the Kulkarni laboratory is to generate functional islet cells for replacing dysfunctional and/or absent hormone producing cells in type 1 and type 2 diabetes. The Kulkarni lab has approached this problem in three ways: First, there is a long standing interest in generating and phenotyping multiple genetically engineered models that have a loss or gain of function of key proteins in the growth factor signaling pathway. Second, the lab has generated induced pluripotent stem cells from patients with type 1, type 2 or maturity onset diabetes of the young (MODY) and ongoing efforts are centered on differentiating the iPS cells towards the pancreatic lineage. A third area of interest is to identify novel circulating growth factors that can enhance proliferation of hormone producing cells in a safe, specific and reversible manner that can be harnessed to therapeutically regenerate human islet cells.
Rohit Kulkarni obtained his MD and PHD degrees from St. John’s Medical College and the Royal Postgraduate Medical School in London where he trained in the lab of Steve Bloom. Subsequently, he obtained the NIH NRSA Award and completed a Postdoctoral Fellowship in the lab of Ron Kahn at the Joslin Diabetes Center. He has been on the Faculty of the Joslin Diabetes Center since 1999 and is currently a Senior Investigator and Associate Professor of Medicine at Harvard Medical School. He is the recipient of the Endocrine Society’s Ernst Oppenheimer Award, the Merck Frosst Distinguished Lectureship and James H. Horner Distinguished Visiting Professorship and is an elected member of the American Society for Clinical Investigation and Association of American Physicians.