Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system. We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body. Read more about Suneet Agarwal, MD, PhD
Dana-Farber Cancer Institute Boston Children's Hospital Harvard Medical School | Broad Institute of MIT and Harvard
The Armstrong laboratory is focused on the mechanisms of cancer development with a focus on leukemia. One major interest in the lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia. The lab is also studying the role of histone modifications and chromosome Read more about Scott Armstrong, MD, PhD
Boston Children's Hospital Dana-Farber Cancer Institute Harvard Medical School
Our laboratory studies the genetic determinants of blood cell ontogeny and disease. We use molecular genetic, biochemical, and genome editing methodologies
Dana-Farber/Boston Children's Hospital Harvard Medical School
Hematopoietic stem cell (HSC) progeny can represent a vehicle for therapeutic molecule delivery to the Central Nervous System (CNS) upon transplantation in
Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice. Read more about David Breault, MD, PhD
Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies. Read more about Alan Cantor, MD, PhD
Craft Lab research Our research focuses on both developmental biology and translational medicine, and involves the use of pluripotent stem cells to understand how musculoskeletal lineages, primarily articular chondrocytes and cartilage tissues, are specified during embryonic development and how mature cells and Read more about April M. Craft, PhD
Dean, Faculty of Medicine, Harvard Medical School Boston Children's Hospital Howard Hughes Medical Institute
George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008). Read more about George Q. Daley, MD, PhD
Associate Professor of Pediatrics and Dermatology, Harvard Medical School
Markus Frank’s laboratory research focuses on the physiological and pathological roles of the P-glycoprotein family of ATP-binding cassette (ABC) multidrug
The laboratory research focus is to understand the pathways of how small regulatory RNAs are generated, how they exert their gene regulatory function, and their role in the self-renewal and pluripotency of embryonic stem (ES) cells. Read more about Richard I. Gregory, PhD
Harvard Medical School Boston Children's Hospital Dana-Farber Cancer Institute
Developing neural repair strategies to restore functions after central nervous system (CNS) injury such as spinal cord injury is still an unmet challenge.
The broad interest of our lab is to characterize the biology of stem cells in normal lung and lung cancer. We developed a method to isolate the first stem
