Co-lead of HSCI's Nervous System Diseases Program Paola Arlotta and postdoctoral fellow Giorgia Quadrato have produced long-cultured brain organoids that have the potential to advance our understanding of brain development and disorders. Photo… Read more about Long-cultured organoids open new vistas for brain disorder research

Bone marrow from a young boy diagnosed with Diamond-Blackfan anemia (DBA) shows a reduced number of erythroid precursor cells. In this case, an unusual gene mutation in the hormone EPO was identified and found to cause the anemia. Photo courtesy of Ekrem Unal.

Adapted from a Joslin Diabetes Center press release

Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets. Using newly identified cellular markers of aging, Joslin Diabetes Center scientists now have shown that this diversity may be driven at least in part by differently aged beta cell populations within the pancreas. 

Additionally, the Joslin team demonstrated that the aging of beta cells, with associated losses of their… Read more about How insulin-producing cells show their age

Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome

Adapted from a Boston Children's Hospital and Massachusetts Eye and Ear press release