Research Update

Tracking an organism’s development, cell by cell

May 29, 2020

HSCI scientists develop CRISPR-based tool for lineage tracing

A new mouse model allows scientists to track every cell in the body, from the embryo stage until adulthood. The system, published in the journal Cell, could yield a greater understanding of development, aging, and disease.

“The dream of many developmental biologists for decades is a way to reconstruct every single...

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HSCI scientist recognized for outstanding dermatology research

May 26, 2020

HSCI scientist Ya-Chieh Hsu, Ph.D. is the recipient of the 2020 LEO Foundation Award. The award recognizes extraordinary contributions to dermatology research that advance our understanding of skin diseases, and have the potential to pave the way for new and improved treatments.

Hsu is the Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology. She studies how communication among different cell...

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HSCI scientist receives Harrington Prize for sickle cell research

May 18, 2020

HSCI principal faculty member Stuart Orkin, M.D. is the recipient of the 2020 Harrington Prize for Innovation in Medicine. The award, established in 2014 by the Harrington Discovery Institute and the American Society for Clinical Investigation (ASCI), honors physician-scientists who have moved science forward with achievements notable for innovation, creativity and potential for clinical application.

Orkin is the David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School. He is being recognized for breakthrough discoveries about red blood cells that offer...

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Potential drug treatments for telomere diseases

April 24, 2020

HSCI researchers have identified potential drugs to treat telomere diseases such as dyskeratosis congenita (DC), in which cells age prematurely. The researchers tested over 100,000 compounds on patient stem cells, and identified several drugs that restored  the cells’ telomeres — the protective caps on the ends of chromosomes that regulate how cells age.

“We envision these to be a new class of oral medicines that target stem cells throughout the body,” said Suneet Agarwal, an HSCI principal faculty member at Boston Children’s Hospital. “We expect restoring telomeres in...

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