Guo-Cheng Yuan, Ph.D.
Dana-Farber Cancer Institute
The Yuan lab develops systems biology approaches to study the cellular mechanisms for tissue development and human diseases.
We develop novel computational methods to analyze and integrate genome-scale datasets, and partner with experimental biologists to discover the underlying gene pathways and regulatory networks.
Our long-term goal is to gain systems-level understanding of the regulatory mechanisms underlying cell-state maintenance and transitions. Our computational methods are used to systematically characterize and predict the function of the genome and regulatory proteins.
We are particularly interested in studying the organization and function of chromatin states, gene regulatory networks, and single-cell genomics. We have applied these approaches to various biological systems such as embryonic stem cell, hematopoiesis, and cancer, in collaboration with numerous experimental groups.
Guo-Cheng Yuan is Associate Professor of Biostatistics at the Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health. He received his B.Sc. and M.A. degrees from Peking University, China, and his Ph.D. in Mathematics from University of Maryland at College Park. Dr. Yuan’s prior work experience spanned diverse fields, including chaos theory and weather prediction. He completed postdoctoral training in Computational Biology at Harvard University.