Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system. We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body.... Read more about Suneet Agarwal, MD, PhD
Chair, Harvard Department of Stem Cell and Regenerative Biology Golub Family Professor of Stem Cell and Regenerative Biology, Harvard University Associate Member, Stanley Center for Psychiatric Research, Broad Institute
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex
The execution of critical behaviors like movement, emotion, and intelligence relies on the orchestrated integration into functional circuits of an outstanding diversity of neuronal subtypes. Focusing on excitatory pyramidal neurons of the mammalian cerebral cortex, our work aims to understand the... Read more about Paola Arlotta, Ph.D.
Dana-Farber Cancer Institute Boston Children's Hospital Harvard Medical School | Broad Institute of MIT and Harvard
The Armstrong laboratory is focused on the mechanisms of cancer development with a focus on leukemia. One major interest in the lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia. The lab is also studying the role of histone modifications and chromosome ... Read more about Scott Armstrong, MD, PhD
Dana-Farber/Boston Children's Hospital Harvard Medical School
Hematopoietic stem cell (HSC) progeny can represent a vehicle for therapeutic molecule delivery to the Central Nervous System (CNS) upon transplantation in...
Joslin Diabetes Center Harvard Medical School Department of Genetics
Using the model organism C. elegans, we study how regulatory pathways that are important in growth control influence stress defenses and aging, as well as relationships between stem cell function and aging.... Read more about Keith Blackwell, MD, PhD
With a series of rodent models, Dr. Bonner-Weir has provided compelling evidence that adult pancreatic beta-cell mass increases in response to a metabolic need and her lab has been examining the mechanisms of postnatal pancreatic growth. More broadly, her lab's focus is on how the pancreatic beta cell changes with age and response to challenges.... Read more about Susan Bonner-Weir, PhD
Dr. Bonventre is Chief of the Renal Unit and Chief of the Engineering in Medicine Division at Brigham and Women's Hospital and has had a long-standing...
Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice.... Read more about David Breault, MD, PhD
Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies.... Read more about Alan Cantor, MD, PhD
Beth Israel Deaconess Medical Center Harvard Medical School Wyss Institute for Biologically Inspired Engineering
Elliot L. Chaikof, MD, PhD, has promoted alliances of clinicians, engineers, chemists, and biologists and in the process developed biologically-inspired materials, devices, and pharmacotherapeutics based upon the principles of molecular engineering and nanofabrication technologies. These endeavors have enabled advances in cell-based therapies, artificial organs, and engineered living tissues, which define the evolving field of Regenerative Medicine.... Read more about Elliot Chaikof, MD, PhD
