Yi Zhang, PhD
Harvard Medical School
Dr. Zhang serves as the Fred S. Rosen endowed Professor of Pediatrics and as Professor of Genetics at Harvard Medical School. He currently is an Investigator of the Howard Hughes Medical Institute. Dr. Zhang's research is focused on epigenetic modifications, particularly DNA methylation and covalent histone modifications, which play an important role in regulating chromatin dynamics, and therefore have a significant impact on gene expression. He and his group have investigated how epigenetic modification-mediated dynamic changes in chromatin structure affect gene expression, cell lineage commitment, stem cell pluripotency, and stem cell self-renewal. In addition, they have studied mis-regulation of epigenetic factors and how that contributes to the development of diabetes, neurological diseases, and cancer. His long-term goal is to apply what they have learned in basic research to the studies of human diseases. His lab has broadened their research interests to include the epigenetic mechanisms in embryonic development, stem cell reprogramming, β-cell regeneration, and drug addiction.