Mario Suva, M.D., Ph.D.
Neuro-Oncology Program, Dana-Farber/Harvard Cancer Center
Institute Member, Broad Institute of MIT and Harvard
Mario Suva's research is focused on the biology of brain tumors, in particular diffuse high-grade gliomas in adults and children.
We dissect how cellular heterogeneity and plasticity contribute to tumor properties. We study primary human samples at single-cell resolution and establish genetically and epigenetically relevant cellular models from patient tumors. We model how brain cancer cells exploit their plasticity to establish distinct epigenetic programs. We seek to identify common programs that would offer novel therapeutic options in these dismal diseases.
We are leading large-scale efforts in single-cell transcriptional profiling in clinical gliomas in adults with our collaborators at the Broad Institute, and extending our single-cell genomics efforts to characterize the immune compartment of clinical gliomas at unprecedented scale and resolution. We are also using the knowledge we have gained of the determinants and plasticity to develop novel, rational approaches to coordinately target the multiple cellular states of glioblastoma.
Mario Suva is an Associate Professor of Pathology at Harvard Medical School; an Associate Molecular Pathologist, Pathology at Massachusetts General Hospital; a member of the Neuro-Oncology Program at the Dana-Farber Cancer Institute; and an Institue Member of the Broad Institute of MIT and Harvard.
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