Jason D. Buenrostro, PhD
Broad Institute of MIT and Harvard
The Buenrostro lab seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods for single-cell ATAC-seq, an increasingly popular method to measure the epigenomes of single-cells. Altogether, we broadly apply these tools to study dynamic cellular systems, including the epigenetic mechanisms underlying cell fate decisions in hematopoiesis and leukemia development.