Jason D. Buenrostro, Ph.D.
Broad Institute of MIT and Harvard
The Buenrostro lab seeks to advance our understanding of gene regulation biology using single-cell methods.
To do this, they develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods for single-cell ATAC-seq, an increasingly popular method to measure the epigenomes of single-cells. Altogether, we broadly apply these tools to study dynamic cellular systems, including the epigenetic mechanisms underlying cell fate decisions in hematopoiesis and leukemia development.
ATAC-seq was first developed by Buenrostro and colleagues in 2013 and its use is now ubiquitous in genomics — for example in major efforts like the Human Cell Atlas project to understand and map genome function. As a reflection of the impact of this work, MIT’s Technology Review named Buenrostro as one of its 2019 “Innovators under 35”.
Jason Buenrostro is an associate member of the Broad Institute, and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. He was formerly a fellow in the Broad Fellows program at the Broad, and a junior fellow at the Harvard University Society of Fellows.
Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at the Stanford University Department of Genetics. At Stanford University he developed new high-throughput genomics methods for enabling a quantitative understanding of gene regulation.