The Buenrostro lab is broadly dedicated to advancing our knowledge of gene regulation and the downstream consequences on cell fate decisions.

To do this, the Buenrostro lab develops new technologies utilizing molecular biology, microscopy and bioinformatics approaches and applies these tools to study stem cells in normal, ageing and cancer tissues in effort to discover chromatin regulators and their contribution to disease.

ATAC-seq was first developed by Buenrostro and colleagues in 2013 and its use is now ubiquitous in genomics — for example in major efforts like the Human Cell Atlas project to understand and map genome function. As a reflection of the impact of this work, MIT’s Technology Review named Buenrostro as one of its 2019 “Innovators under 35”.

Biosketch

Jason Buenrostro is an associate member of the Broad Institute, and the Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology at Harvard University. He was formerly a fellow in the Broad Fellows program at the Broad, and a junior fellow at the Harvard University Society of Fellows.

Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at the Stanford University Department of Genetics. At Stanford University he developed new high-throughput genomics methods for enabling a quantitative understanding of gene regulation.