Winston Hide, PhD
Understanding development arising from stem cells using molecular profiles like gene expression microarray, genome wide methylation marks, RNASeq, and histone mark dynamics is currently our state of the art. All of these approaches measure a single dimension of molecular event. How can this be translated to how the cell is functioning at the developmental time point, and how can this be compared between experiments that are using different platforms, cell types, and whatever else?
We need to figure out what the overall functional state of the cell is at the developmental snapshot we are taking. If we can do that then its possible to compare functional states – which are made up of the sum of the assay activities we are performing already, and draw the conclusions accordingly.
We apply systematic organizing approaches to data from the genome, transcriptomics, protein-protein interaction and gene regulation and so reveal critical processes that protect against the onset of neurodegeneration.
I am co-Director of the Non-Coding RNA Precision Diagnostics and Therapeutics Core Facility at BIDMC where we perform specialized bioinformatics for interpretation of ncRNA discoveries for delivery novel RNA therapeutics.