One of the reasons renal failure is so common is the inability of our kidneys to form new nephrons (the functional unit of the kidney). The focus of the HSCI Kidney Program is to understand the biology, differentiation, maintenance, repair, and diseases of the nephron, with the goal of developing new therapies.
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Key Research Questions
The HSCI Kidney Program employs the use of patient-derived iPS cells, transgenic tools, and zebrafish disease models to answer the following questions:
- What are the molecular mechanisms that drive nephron regeneration?
- What are the precursors of kidney tubule cells?
- How is renal stem cell proliferation regulated?
Key Scientific Results
Scientific findings from the HSCI Kidney Program include:
- The differentiation of kidney tubule cells from stem cells.
- The clarification that cells replacing epithelial cells after injury are derived from the epithelium itself rather than a population of interstitial stem cells.
- The discovery that there is no specific population of proximal tubule cells that is responsible for replacement of dead cells and that surviving cells dedifferentiate and undergo cell division.
- The finding that individual nephrons do not come from individual progenitor cells. Rather, two different cell types coalesce to form nephrogenic aggregates, a process reminiscent of embryonic mammalian nephron generation.
- The elaboration that a major factor in the development of fibrosis is cell cycle arrest in the proximal epithelial cell.