Gastrointestinal Disease

Gut-brain connection in autism

January 7, 2022

Harvard and MIT researchers identify possible mechanism linking autism and intestinal inflammation

Many people with autism spectrum disorders also experience unusual gastrointestinal inflammation, but thus far scientists have not established whether and how those conditions might be linked.

Now, Harvard Stem Cell Institute (HSCI) researchers at Harvard Medical School, along with MIT researchers, may have found the missing link: infections during pregnancy can lead to high levels of the inflammatory signaling molecule interleukin-17a (...

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Harald Ott and team from MGH creates functional, stem cell-derived small bowel segments

October 10, 2017

Press release of the Massachusetts General Hospital

Using human induced pluripotent stem cells (iPSCs), a Massachusetts General Hospital (MGH) research team has bioengineered functional small intestine segments that, when implanted into rats, were capable of deliver nutrients into the bloodstream. The investigators describe their accomplishment in the online journal Nature Communications.

“In this study we have been able to bridge the gap between differentiation of single cells – driving stem cells to become a specific cell type – and the...

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