Benjamin Humphreys, MD, PhD
Dana-Farber Cancer Institute
Harvard Medical School
The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney injury and repair and to translate this knowledge into new therapeutic strategies to treat patients suffering from kidney disease. We use mouse genetics, genomic techniques and traditional molecular and biochemical approaches to study and model human kidney disease. The work encompasses two main areas: (1) Acute kidney injury with an emphasis on the signaling pathways that enable productive kidney repair. We have identified novel pathways regulating epithelial proliferation and re-differentiation after injury, and are investigating small-molecule based strategies to accelerate this repair process in vivo. We also study (2) Chronic kidney disease which represents a major unmet clinical need worldwide and causes kidney failure and the need for either dialysis or transplantation. Here, we identify the cells responsible for kidney fibrosis and design new approaches to limit the damage these cells do to kidney tissue.
Dr. Humphreys is an Assistant Professor of Medicine at Harvard Medical School. He received a bachelor's degree from Harvard College and MD and PhD degrees from Case Western Reserve University. He completed a residency in Internal Medicine at Massachusetts General Hospital and a fellowship in Nephrology at Brigham and Women's Hospital.