In the Clinic

Suneet Agarwal, MD, PhD

Suneet Agarwal, MD, PhD

Boston Children's Hospital

Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system.  We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body. 

M. Amin Arnaout, MD

M. Amin Arnaout, MD

Massachusetts General Hospital

A major research focus of my laboratory is the dissection of the role of leukocyte integrins in inflammation, and an elucidation of the mechanisms that regulate the functions of these adhesion receptors in health and disease.

Joseph V. Bonventre, MD, PhD

Joseph V. Bonventre, MD, PhD

Brigham and Women's Hospital

Dr. Bonventre is Chief of the Renal Unit and Director of the Bioengineering Division at Brigham and Women’s Hospital and has had a long-standing interest in various aspects of cellular injury and repair mechanisms in the kidney with a special emphasis on the role of inflammation, biomarkers and stem cells.

David Breault, MD, PhD

David Breault, MD, PhD

Boston Children's Hospital

Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice.

Alan Cantor, MD, PhD

Alan Cantor, MD, PhD

Boston Children's Hospital

Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies.

Elliot Chaikof, MD, PhD

Elliot Chaikof, MD, PhD

Beth Israel Deaconess Medical Center
Harvard Medical School
Wyss Institute for Biologically Inspired Engineering

Elliot L. Chaikof, MD, PhD, has promoted alliances of clinicians, engineers, chemists, and biologists and in the process developed biologically-inspired materials, devices, and pharmacotherapeutics based upon the principles of molecular engineering and nanofabrication technologies. These endeavors have enabled advances in cell-based therapies, artificial organs, and engineered living tissues, which define the evolving field of Regenerative Medicine.

George Q. Daley, MD, PhD

George Q. Daley, MD, PhD

Boston Children's Hospital
Harvard Medical School
Howard Hughes Medical Institute

George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008). 

Patricia K. Donahoe, MD

Patricia K. Donahoe, MD

Massachusetts General Hospital
Harvard Medical School

The Pediatric Surgical Research Laboratories focus on Developmental Biology, some areas of which hold promise for clinical application to benefit both pediatric and adult patients.

Susan Dymecki, MD, PhD

Susan Dymecki, MD, PhD

Harvard Medical School

The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification, differentiation, and migration paths taken by specific sets of cells originating from primitive neuroectoderm.

Benjamin Ebert, MD

Benjamin Ebert, MD

Brigham and Women's Hospital
Harvard Medical School

We study the biology and treatment of cancer using hematopoiesis as a model system. The laboratory employs a range of genomic technologies as well as classical cellular and molecular biology approaches to investigate the biology of specific human diseases, particularly hematopoietic malignancies and disorders of red blood cell production.

Wolfram Goessling, MD, PhD

Wolfram Goessling, MD, PhD

Brigham and Women's Hospital
Dana-Farber Cancer Institute
Harvard Medical School

Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth.