Harvard Department of Stem Cell and Regenerative Biology

Paola Arlotta, PhD

Paola Arlotta, PhD

Harvard University Department of Stem Cell and Regenerative Biology

During embryonic development, neural progenitors undergo precise differentiation to generate the amazing variety of neuronal types that ultimately populate the mature brain. While some of the basic mechanisms that control general aspects of progenitor specification into neurons have been defined, the genetic programs that control the differentiation of distinct types of neurons in the brain are still largely unknown.

Chad Cowan, PhD

Chad Cowan, PhD

Harvard University Department of Stem Cell and Regenerative Biology
Massachusetts General Hospital

Our research is focused on understanding the molecular underpinnings of metabolic diseases such as type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).

Kevin C. Eggan, PhD

Kevin C. Eggan, PhD

Harvard University Department of Stem Cell and Regenerative Biology
Howard Hughes Medical Institute

As a young investigator in the burgeoning field of stem cell biology, Dr. Eggan has garnered international recognition for his seminal work and a number of high profile awards for his creativity and productivity, including the MacArthur Foundation “Genius Grant” in 2006. His current research focuses on applying the knowledge gained in stem cell biology to studying the mechanisms underlying amyotrophic lateral sclerosis (ALS) and discovering new therapeutic targets.

Ya-Chieh Hsu, PhD

Ya-Chieh Hsu, PhD

Harvard Department of Stem Cell and Regenerative Biology

We study how growth and differentiation are controlled, and how different cell types coordinate with one another, to maintain tissue function during development, regeneration, and repair.

Richard Lee, MD

Richard Lee, MD

Brigham and Women's Hospital
Harvard University Department of Stem Cell and Regenerative Biology
Harvard Medical School

The Lee Laboratory uses biotechnologies to discover and design new approaches to cardiovascular and metabolic diseases. We work at this interface using a broad variety of techniques in genomics, stem cell biology, and molecular biology. Our approach is to understand human problems and design solutions in the laboratory, and then we demonstrate the effectiveness of these solutions in vivo. Ongoing projects in the laboratory include studies of cardiac regeneration, diabetes, aging and metabolism.

Jeffrey D. Macklis, MD

Jeffrey D. Macklis, MD

Harvard University Department of Stem Cell and Regenerative Biology

Our laboratory is directed toward both 1) understanding the molecular controls over neuron sub-type specification and development in the cerebral cortex, and 2) applying developmental controls toward brain and spinal cord repair—specifically, the cellular repair of complex cerebral cortex and cortical output circuitry (in particular, cortico-spinal motor neuron (CSMN) circuitry that degenerates in ALS and other “upper motor neuron” degenerative diseases, and whose injury is centrally involved in loss of motor function in spinal cord injury).

Kiran Musunuru, MD, PhD, MPH

Kiran Musunuru, MD, PhD, MPH

Harvard University Department of Stem Cell and Regenerative Biology
Brigham and Women's Hospital
The Broad Institute

Our goal is to understand how naturally occurring human genetic variation protects (or predisposes) some people to cardiovascular and metabolic disease—the leading cause of death in the world—and to use that information to develop therapies that can protect the entire population from disease.

John Rinn, PhD

John Rinn, PhD

Harvard University Department of Stem Cell and Regenerative Biology

Our research aims to understand the role of long intergenic non-coding RNAs (lincRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer.

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