The Rubin laboratory in the Department of Stem Cell and Regenerative Biology at Harvard University is focused on studying complex molecular pathways underlying different disease states, especially late onset neurodegenerative disorders and neuromuscular diseases, with a goal of identifying novel therapeutic avenues. In our skeletal muscle projects, our studies evaluate whether or not defects in satellite cells may contribute to neuromuscular diseases. Our research combines the use of primary patient-derived cells (iPSCs, myogenic progenitors), genetic mouse models, and phenotypic drug screening methods. In addition we are examining severe muscle damage that results in a less efficient regenerative process. We use a combination of human and mouse in vivo and in vitro studies to carry out chemical screening and transcriptional profiling analyses to evaluate potential therapeutics related to targeting satellite cells.
A Postdoctoral position is now available for individuals with a background in skeletal muscle regeneration and satellite cell biology. Studies will range from muscle functional assays (quantification of muscle force), isolation and culture of satellite cells, and the mechanistic study of pathways required to confer satellite cell regenerative capacity.
A Ph.D. in satellite cell biology, developmental biology or cell/molecular biology is required. Some familiarity with cell culture, FACS, transcriptional or epigenetic profiling along with mouse husbandry and knowledge of skeletal muscle functional assays is preferred.
To apply, email a cover letter, CV, names and contact information (email, address, and telephone number) of three references to Dr. Lee Rubin (email@example.com).
Applications from women and minority candidates are encouraged. Harvard University is an Affirmative Action/Equal Opportunity Employer.