When the Hippo pathway is inactivated, mature liver cells revert back to a stem cell-like state. Picture shows a group of cells transitioning from a mature cell type (green) to a stem cell type (red). White cells are the cells where Hippo is
Harvard stem cell scientists studying the effect of nitric oxide on liver growth and regeneration appear to have serendipitously discovered a markedly improved treatment for liver damage caused by acetaminophen toxicity—the cause of half the U.S. hospital visits related to acute liver failure.
Harvard stem cell scientists have a new theory for how stem cells decide whether to become liver or pancreatic cells during development. A cell’s fate, the researchers found, is determined by the nearby presence of prostaglandin E2, a messenger molecule best known for its role in inflammation and pain. The