This story was originally posted by Beth Israel Deaconess Medical Center.

New findings could help lead to drug treatment to prevent dangerous genetic heart disease

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Harvard researchers show that it’s plausible

Kiran Musunuru, MD, PhD (Credit: B.D. Colen/Harvard University)

Harvard Stem Cell Institute (HSCI) scientists collaborating with researchers at...

Cross-Harvard collaboration explores new possibilities for personalized medicine

Harvard scientists have merged stem cell and ‘organ-on-a-chip’ technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine, as it is working proof that a chunk of tissue containing a patient’s specific genetic...

Harvard Stem Cell Institute researchers at Massachusetts General Hospital have identified the earliest master human heart stem cell from human embryonic stem cells – ISL1+ progenitors – that give rise to a family of cells that form the essential portions of the human heart.... Read more about Human cardiac master stem cells identified

Recent research has shown that there are new cells that develop in the heart, but how these cardiac cells are born and how frequently they are generated remains unclear.

In a study from Harvard-affiliated Brigham and Women’s Hospital (BWH), researchers used a...

Harvard Stem Cell Institute researchers at Massachusetts General Hospital (MGH) succeeded in using reprogrammed human stem cells to make working blood vessels in mice that can survive for as long as nine months. The blood vessels were created with induced pluripotent stem cells (iPSCs) derived from the mature skin cells of both healthy adults and individuals with type 1 diabetes.... Read more about Long-lasting blood vessels generated from human iPS cells

Heart attacks cause the death of billions of the heart’s muscle cells. If these cardiomyocytes could be made to regenerate after an infarct, the heart could potentially be mended and its function restored.... Read more about Modified RNA offers drug-like approach to regenerating heart tissue

In a scientific first, HSCI scientists have successfully grown the cells that line the blood vessels—called vascular endothelial cells—from human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function. Using a unique approach, the researchers...