Eye Diseases

2022 HSCI Nervous System Disease Program Request for Proposals on Vision Repair and Regeneration

November 22, 2021

2022 HSCI Nervous System Disease Program

Request for Proposals on Vision Repair and Regeneration

 

AWARD AMOUNT

Trainee Awards will be made in amounts of up to $75,000 total funding per year.

Faculty Awards will be made in amounts of up to $150,000 total funding per year.

Up to $300,000 for entire project period.

Project period not to exceed 2 years

 

DEADLINE FOR LETTER OF INTENT

** EXTENDED **
Wednesday, February 2, 2022

 

DEADLINE FOR FULL PROPOSAL

** EXTENDED **
Friday, February 25, 2022

 

ANTICIPATED AWARD DATE

April 1, 2022

 

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Restoring vision

November 26, 2019

A stem cell therapy for cornea regeneration reaches the clinical-trial stage

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By Jessica Lau

As the eye’s outer layer of protection, the cornea needs to constantly regenerate to maintain a clear surface. Losing the cornea-regenerating stem cells leads to cloudiness — like trying to see...

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Healing without scars

November 7, 2018

George Murphy wants to use stem cells to replace scarring with regenerative healing.

  • George Murphy’s goal is to coax skin stem cells into healing wounds by regenerating tissue instead of forming a scar.
  • To figure out how to do it, he is studying scarless healing during fetal development and “stem cell burnout” during aging.
  • Insights into scarless healing will help research into regenerating other vital organs, including the heart.

...

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Can we restore sight?

November 7, 2018

Markus Frank and his colleagues are reprogramming skin cells with the goal of giving people back their sight.

  • Seed funding from HSCI led Markus Frank and his colleagues to discover that the cell surface molecule ABCB5 can be used to identify limbal stem cells, which regenerate the cornea.
  • The team is developing ABCB5-positive cell therapy as a treatment for vision loss due to limbal stem cell deficiency.

Markus Frank, M.D., co-leader of the HSCI Skin Program, is reprogramming stem cells from the skin...

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Seeing the Light

March 25, 2015

HSCI Principal Faculty member Connie Cepko and postdoctoral researcher Wenjun Xiong talk about developing a gene therapy to stave off blindness. Video: Rick Groleau

Gene therapy slows vision loss in mouse models of retinal degeneration

By...

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