Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), in collaboration with Harvard Stem Cell Institute (HSCI), have discovered a new way in which the development of lung cancer can be stopped. In a study published in Science Translational Medicine, the researchers found that inhibiting a protein called BMI1 impaired tumour growth in lung cancer.
The study was led by HSCI Principal Faculty member Daniel Tenen, MD, his associate Elena Levantini, PhD, and included first author Dr Kol Jia Yong, a former
First demonstration of a cancer arising from a single cell
by Nancy Fliesler, Boston Children's Hospital
Harvard Stem Cell Institute researchers at Boston Children’s Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal. Their work, published in the
Mouse rhabdomyosarcoma tumors produced by activated muscle stem cells with high Yap activity (green; top panels) decrease in size when Yap activity is lowered (bottom panels, as shown by the green tumor cells starting to form muscle tissue and express normal muscle differentiation
A Harvard Stem Cell Institute (HSCI) collaboration between a molecular chemist who studies microRNAs and a stem cell biologist interested in cell growth has led to new understanding of what goes wrong in several kinds of cancer.
The general theory of cancer development holds that malignancies occur because of the presence of certain genetic elements within the affected cells.
But a new study by Harvard researchers at Massachusetts General Hospital (MGH) indicates that “good” cells can become cancerous because of exposure to a “bad” environment within the body — similarly to the way a “good boy” may turn to crime when exposed to the pressures of life in a crime-ridden neighborhood.
In their paper in today’s edition of the journal Nature, David T. Scadden and colleagues report that normal blood stem