Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), in collaboration with Harvard Stem Cell Institute (HSCI), have discovered a new way in which the development of lung cancer can be stopped. In a study published in Science Translational Medicine, the researchers found that inhibiting a protein called BMI1 impaired tumour growth in lung cancer.
HSCI researchers sampled biopsies from women participating in the Nurses' Health Study. In healthy breast tissue (pictured above), the percentage of cells expressing molecular marker Ki67 (green) and p27 (red) Read more about New weapon against breast cancer
Mouse rhabdomyosarcoma tumors produced by activated muscle stem cells with high Yap activity (green; top panels) decrease in size when Yap activity is lowered (bottom panels, as shown by the green tumor cells starting to form muscle tissue and express normal muscle differentiation Read more about Molecule that drives rare childhood cancer discovered
A Harvard Stem Cell Institute (HSCI) collaboration between a molecular chemist who studies microRNAs and a stem cell biologist interested in cell growth has led to new understanding of what goes wrong in several kinds of cancer.
The general theory of cancer development holds that malignancies occur because of the presence of certain genetic elements within the affected cells.
But a new study by Harvard researchers at Massachusetts General Hospital (MGH) indicates that “good” cells can become cancerous because of exposure to a “bad” environment within the body — similarly to the way a “good boy” may turn to crime when exposed to the pressures of life in a crime-ridden neighborhood.
Acute myelogenous leukemia (AML) is one of the most common types of leukemia—a cancer of the bone marrow and blood—in adults, affecting about 13,300 women and men in the United States annually. The disease is also diagnosed in hundreds of children in this country each year.