The general theory of cancer development holds that malignancies occur because of the presence of certain genetic elements within the affected cells.
But a new study by Harvard researchers at Massachusetts General Hospital (MGH) indicates that “good” cells can become cancerous because of exposure to a “bad” environment within the body — similarly to the way a “good boy” may turn to crime when exposed to the pressures of life in a crime-ridden neighborhood.
In their paper in today’s edition of the journal Nature, David T. Scadden and colleagues report that normal blood stem...
Acute myelogenous leukemia (AML) is one of the most common types of leukemia—a cancer of the bone marrow and blood—in adults, affecting about 13,300 women and men in the United States annually. The disease is also diagnosed in hundreds of children in this country each year.
Starting with a discovery in zebrafish in 2007, Harvard Stem Cell Institute (HSCI) researchers have published initial results of a Phase Ib human clinical trial of a therapeutic that has the potential to improve the success of blood stem cell transplantation. This milestone, just nine short years after Harvard’s major commitment to stem cell biology, once again demonstrates the ability of HSCI investigators to carry a discovery from the lab bench to the clinic—fulfilling the promise on which the Institute was founded.... Read more about HSCI publishes clinical trial results for therapeutic that amplifies blood stem cells