Genetics/Epigenetics

Yick W. Fong, PhD

Yick W. Fong, PhD

Brigham and Women's Hospital
Harvard Medical School

Transcriptional mechanisms of pluripotency and cellular reprogramming

We study key transcriptional and gene regulatory events that lead to the acquisition and maintenance of pluripotency in embryonic stem cells (ESCs).  ESCs can self-renew or differentiate to produce most of the cells of the body. These distinct but developmentally relevant cell fates are defined by their unique gene expression signatures. Proper execution of these developmental programs requires the precise tuning of gene expression by transcription factors, coactivators and corepressors.  Indeed, aberrant transcriptional regulation is the root of many human diseases including developmental disorders, cancers and degenerative diseases.... Read more about Yick W. Fong, PhD

Winston Hide, PhD

Winston Hide, PhD

Beth Israel Deaconess Medical Center

Understanding development arising from stem cells using molecular profiles like gene expression microarray, genome wide methylation marks, RNASeq, and histone mark dynamics is currently our state of the art. All of these approaches measure a single dimension of molecular event. How can this be translated to how the cell is functioning at the developmental time point, and how can this be compared between experiments that are using different platforms, cell types, and whatever else?... Read more about Winston Hide, PhD

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