Our research is focused on understanding the molecular underpinnings of metabolic diseases such as type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).... Read more about Chad Cowan, Ph.D.

The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.... Read more about Susan Dymecki, MD, PhD

Transcriptional mechanisms of pluripotency and cellular reprogramming

We study key transcriptional and gene regulatory events that lead to the acquisition and maintenance of pluripotency in embryonic stem cells (ESCs).  ESCs can self-renew or differentiate to produce most of the cells of the body. These distinct but developmentally relevant cell fates are defined by their unique gene expression signatures. Proper execution of these developmental programs requires the precise tuning of gene expression by transcription factors, coactivators and corepressors.  Indeed, aberrant transcriptional regulation is the root of many human diseases including developmental disorders, cancers and degenerative diseases.... Read more about Yick W. Fong, PhD

Understanding development arising from stem cells using molecular profiles like gene expression microarray, genome wide methylation marks, RNASeq, and histone mark dynamics is currently our state of the art. All of these approaches measure a single dimension of molecular event. How can this be translated to how the cell is functioning at the developmental time point, and how can this be compared between experiments that are using different platforms, cell types, and whatever else?... Read more about Winston Hide, PhD

Currently I am focused on ways of exploiting the emerging genetics of neuropsychiatric disorders to develop models that will ultimately facilitate the discovery of much needed new therapeutics.... Read more about Steven Hyman, MD

Our lab is interested in the role of functional inputs such as mechanical forces, metabolism or electrical activity in refining the basic programs of cell specification and differentiation in cardiovascular development, disease, repair and regeneration.... Read more about Calum MacRae, MD, PhD