Jonathan G. Hoggatt, Ph.D.
Harvard Medical School
The Hoggatt Lab is focused on tissue regeneration and stem cell biology, with a particular focus on translational research to enhance bone marrow transplantation.
Jon Hoggatt's research group is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages. The lab also has a specific interest in translational science for bone marrow transplantation and other treatments.
Hoggatt and his colleagues have identified a unique "highly engraftable" hematopoietic stem cell that is currently being investigated and has applications for further probing of stem cell niche biology and clinical applications in stem cell transplantation, gene therapy, and other fields. The lab has also developed unique genetic mouse models allowing for the dynamic exploration of macrophage heterogeneity in a variety of disease settings.
Research efforts over the past several decades working to develop therapies have largely focused on finding “magic bullets”, a small molecule or perhaps protein biologic that can be given to a patient as a drug to cure their disease.
We believe the that the cures of the future will come from tapping in to the body’s natural regenerative capacities, or will use cellular therapies, namely stem cell transplantation. Our goal is to discover new regenerative pathways within the body to allow for disease correction and to make stem cell transplantation faster, safer, cheaper, and better to broaden its use to more patients.
Jon Hoggatt holds appointments in both the Cancer Center and Center for Transplantation Sciences. He is also a principal faculty member of the Harvard Stem Cell Institute and a principal faculty member of the Stem Cell and Regenerative Biology Department at Harvard University.
Hoggatt obtained his Ph.D. from Indiana University School of Medicine in 2010, where his dissertation was recognized as the most outstanding amongst all disciplines and awarded the Esther L. Kinsley award. He then completed a post-doctoral fellowship with David Scadden at Harvard University, where he received an HSCI T32 training award, and an NIH Pathway to Independence award.
Hoggatt's work over the past several years has focused on translational science in bone marrow transplantation, and has resulted in several clinical trials and high profile papers in Nature, Nature Medicine, and others. During his graduate studies, Jon served as a Police Commissioner and then later as a City Councilman for West Lafayette, Indiana. He currently serves the American Society of Hematology on the Government Affairs and Communications Committees and is a Contributing Editor of The Hematologist.