Giuseppe Intini, DDS, PhD

Giuseppe Intini, DDS, PhD

Harvard School of Dental Medicine
Giuseppe Intini, DDS, PhD

The research in the Intini laboratory, or the intinilab, as we like to call it, focuses on the biology of the adult skeletal stem cells. We use mouse genetics and in vivo imaging to describe the location of these stem cells within the intramembranous bone, their contribution to tissue repair, the effects of aging on these cells, and the molecular mechanisms that control their "stemness". Similar to what Dr. Yamanaka has described for the iPS cells, we believe that a limited number of genes expressed by adult skeletal stem cells confer the stemness quality to these cells. With the final goal of translating our research into clinically useful information we therefore aim to identify these genes and understand the influence that cellular location or aging has on their expression.

Another project at its initial stages at the intinilab focuses on the role of skeletal stem cells and cancer stem cells in development and maintenance of osteosarcoma. In this project we aim to trace the stem cells and identify mechanisms that may prevent metastasis, the ultimate cause of death in children with osteosarcoma.

Bio-Sketch

Dr. Giuseppe Intini is an Assistant Professor of Oral Medicine, Infection, and Immunity at the Harvard School of Dental Medicine.

Born in Italy, Dr. Intini earned a degree in dentistry in 1995 from the University of L'Aquila in Italy. In 2000, he received a Master's degree in Oral Sciences from the University at Buffalo (USA), and in 2007 he received a Ph.D. in Oral Biology and a certificate in clinical Periodontology from the University at Buffalo (USA). From 2007 to 2012 he has been a postdoctoral fellow at Harvard School of Dental Medicine. He is a Diplomate of the American Board of Periodontology.

As a clinician scientist he has clinical interest in bone augmentation procedures and research interest in bone and cancer stem cell biology.

During his postdoctoral fellowship, his work and teaching have been recognized by the Harvard School of Dental Medicine Dean's Scholar Award, the Young Investigator Travel Award from the American Society of Bone and Mineral Research, the Teaching Fellowship from the American Academy of Periodontology, and the AAP Award for Outstanding Teaching and Mentoring in Periodontics.

In 2010, Dr. Intini was awarded a K99/R00 Pathway to Independence Award from the NIH/NIDCR to study the distribution and activation of osteoprogenitor stem cells in intramembranous bone.

Dr. Intini is an associate editor of the Journal of Translational Medicine and an ad hoc reviewer for scientific journals in the fields of orthopaedics, bone biology, tissue engineering, and periodontology.

Research Interest(s)