The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.... Read more about Susan Dymecki, MD, PhD
Dana-Farber Cancer Institute Brigham and Women's Hospital Harvard Medical School
Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used in the treatment of patients with hematologic malignancies, but continues to be associated with severe toxicities. Both the effectiveness and toxicity of HSCT are mediated by donor T-cells in the stem cell graft. Those T cells that target antigens expressed on recipient leukemia cells play an important role in eradicating residual tumor cells and preventing leukemia relapse after transplant. In contrast, T cells that target antigens expressed by normal tissues in the recipient are the primary mediators of graft versus host disease (GVHD) and thus lead to substantial toxicities. My laboratory focuses on the assessment of donor immune function after HSCT and characterization of the immune mechanisms responsible for graft versus leukemia (GVL) and GVHD.... Read more about Jerome Ritz, MD
Harvard Department of Stem Cell and Regenerative Biology Principal Faculty, Harvard Stem Cell Institute Co-chair, HSCI Nervous System Disease Program
Dr. Lee Rubin, co-leader of the HSCI Nervous System Diseases Program, has a broad experience in translational neuroscience research in both academia and industry. ... Read more about Lee L. Rubin, Ph.D.
Co-chair, Harvard Department of Stem Cell and Regenerative Biology Senior Investigator, Islet Cell and Regenerative Biology, Joslin Diabetes Center
Stem cells are rare and unique cells capable of generating many different types of cells needed in the body. In adult tissues, different organs contain different stem cell populations, each of which produces a subset of the body's cells. For example, hematopoietic (blood-forming) stem cells generate all of the red and white blood cells needed to deliver oxygen to body tissues, fight infection, and stop bleeding. Similarly, myogenic (muscle-forming) stem cells generate mature muscle fibers necessary for controlled contraction of skeletal muscle. Work in the Wagers Lab focuses on understanding the mechanisms that regulate the function of these blood-forming and muscle-forming stem cells so that their potential can be optimally exploited for the treatment of diseases such as cancer, anemia, muscular dystrophy, and diabetes.... Read more about Amy Wagers, PhD