Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system. We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body.... Read more about Suneet Agarwal, MD, PhD
Dana-Farber Cancer Institute Boston Children's Hospital Harvard Medical School | Broad Institute of MIT and Harvard
The Armstrong laboratory is focused on the mechanisms of cancer development with a focus on leukemia. One major interest in the lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia. The lab is also studying the role of histone modifications and chromosome ... Read more about Scott Armstrong, MD, PhD
Joslin Diabetes Center Harvard Medical School Department of Genetics
Using the model organism C. elegans, we study how regulatory pathways that are important in growth control influence stress defenses and aging, as well as relationships between stem cell function and aging.... Read more about Keith Blackwell, MD, PhD
Dr. Bonventre is Chief of the Renal Unit and Chief of the Engineering in Medicine Division at Brigham and Women's Hospital and has had a long-standing...
Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice.... Read more about David Breault, MD, PhD
Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies.... Read more about Alan Cantor, MD, PhD
Beth Israel Deaconess Medical Center Harvard Medical School Wyss Institute for Biologically Inspired Engineering
Elliot L. Chaikof, MD, PhD, has promoted alliances of clinicians, engineers, chemists, and biologists and in the process developed biologically-inspired materials, devices, and pharmacotherapeutics based upon the principles of molecular engineering and nanofabrication technologies. These endeavors have enabled advances in cell-based therapies, artificial organs, and engineered living tissues, which define the evolving field of Regenerative Medicine.... Read more about Elliot Chaikof, MD, PhD
Dean, Faculty of Medicine, Harvard Medical School Boston Children's Hospital Howard Hughes Medical Institute
George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008).... Read more about George Q. Daley, MD, PhD
The Domian Laboratory is focused on adapting findings of basic developmental and stem cell biology to translational cardiovascular medicine.... Read more about Ibrahim Domian, MD, PhD
Massachusetts General Hospital Harvard Medical School
The Pediatric Surgical Research Laboratories focus on Developmental Biology, some areas of which hold promise for clinical application to benefit both pediatric and adult patients.... Read more about Patricia K. Donahoe, MD
The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.... Read more about Susan Dymecki, MD, PhD
Brigham and Women's Hospital Dana-Farber Cancer Institute Harvard Medical School | Broad Institute
The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that predict prognosis and response to therapies in MDS patients. The also focuses on a pre-... Read more about Benjamin L. Ebert, MD, PhD
Brigham and Women's Hospital Dana-Farber Cancer Institute Harvard Medical School
Fatty liver disease affects >90 million people in the U.S., chronic liver is the 12th leading cause of death, and liver cancer is one of the fastest growing cancers in the U.S. None of these conditions have promising and widely effective therapies.... Read more about Wolfram Goessling, MD, PhD
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia. All blood cells arise from a small population...
