In the Clinic

Suneet Agarwal, MD, PhD

Suneet Agarwal, MD, PhD

Boston Children's Hospital

Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system.  We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body.  Read more about Suneet Agarwal, MD, PhD

Scott Armstrong MD PhD photo

Scott Armstrong, MD, PhD

Dana-Farber Cancer Institute
Boston Children's Hospital
Harvard Medical School | Broad Institute of MIT and Harvard

The Armstrong laboratory is focused on the mechanisms of cancer development with a focus on leukemia. One major interest in the lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia. The lab is also studying the role of histone modifications and chromosome Read more about Scott Armstrong, MD, PhD

Elliot Chaikof, MD, PhD

Elliot Chaikof, MD, PhD

Beth Israel Deaconess Medical Center
Harvard Medical School
Wyss Institute for Biologically Inspired Engineering

Elliot L. Chaikof, MD, PhD, has promoted alliances of clinicians, engineers, chemists, and biologists and in the process developed biologically-inspired materials, devices, and pharmacotherapeutics based upon the principles of molecular engineering and nanofabrication technologies. These endeavors have enabled advances in cell-based therapies, artificial organs, and engineered living tissues, which define the evolving field of Regenerative Medicine. Read more about Elliot Chaikof, MD, PhD

George Q. Daley, MD, PhD

George Q. Daley, MD, PhD

Dean, Faculty of Medicine, Harvard Medical School
Boston Children's Hospital
Howard Hughes Medical Institute

George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008).  Read more about George Q. Daley, MD, PhD

Susan Dymecki, MD, PhD

Susan Dymecki, MD, PhD

Harvard Medical School

The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification, differentiation, and migration paths taken by specific sets of cells originating from primitive neuroectoderm. Read more about Susan Dymecki, MD, PhD

Benjamin Ebert, MD, PhD

Benjamin Ebert, MD, PhD

Brigham and Women's Hospital
Harvard Medical School

The primary focus of the Ebert laboratory is the biology and treatment of clonal hematopoiesis and myeloid malignancies. Our genetic studies have led to the characterization of clonal hematopoiesis of indeterminate potential (CHIP) and the identification of mutations in MDS that predict overall survival, outcome following bone marrow transplantation, Read more about Benjamin Ebert, MD, PhD

Wolfram Goessling, MD, PhD

Wolfram Goessling, MD, PhD

Brigham and Women's Hospital
Dana-Farber Cancer Institute
Harvard Medical School

Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth. Read more about Wolfram Goessling, MD, PhD