Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system. We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body. Read more about Suneet Agarwal, MD, PhD
Dana-Farber Cancer Institute Boston Children's Hospital Harvard Medical School | Broad Institute of MIT and Harvard
The Armstrong laboratory is focused on the mechanisms of cancer development with a focus on leukemia. One major interest in the lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia. The lab is also studying the role of histone modifications and chromosome Read more about Scott Armstrong, MD, PhD
A major research focus of my laboratory is the dissection of the role of leukocyte integrins in inflammation, and an elucidation of the mechanisms that regulate the functions of these adhesion receptors in health and disease. Read more about M. Amin Arnaout, MD
Boston Children's Hospital Dana-Farber Cancer Institute Harvard Medical School
Our laboratory studies the genetic determinants of blood cell ontogeny and disease. We use molecular genetic, biochemical, and genome editing methodologies
Joslin Diabetes Center Harvard Medical School Department of Genetics
Using the model organism C. elegans, we study how regulatory pathways that are important in growth control influence stress defenses and aging, as well as relationships between stem cell function and aging. Read more about Keith Blackwell, MD, PhD
Dr. Bonventre is Chief of the Renal Unit and Director of the Bioengineering Division at Brigham and Women’s Hospital and has had a long-standing interest in various aspects of cellular injury and repair mechanisms in the kidney with a special emphasis on the role of inflammation, biomarkers and stem cells. Read more about Joseph V. Bonventre, MD, PhD
Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice. Read more about David Breault, MD, PhD
Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies. Read more about Alan Cantor, MD, PhD
Beth Israel Deaconess Medical Center Harvard Medical School Wyss Institute for Biologically Inspired Engineering
Elliot L. Chaikof, MD, PhD, has promoted alliances of clinicians, engineers, chemists, and biologists and in the process developed biologically-inspired materials, devices, and pharmacotherapeutics based upon the principles of molecular engineering and nanofabrication technologies. These endeavors have enabled advances in cell-based therapies, artificial organs, and engineered living tissues, which define the evolving field of Regenerative Medicine. Read more about Elliot Chaikof, MD, PhD
Dean, Faculty of Medicine, Harvard Medical School Boston Children's Hospital Howard Hughes Medical Institute
George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008). Read more about George Q. Daley, MD, PhD
The Domian Laboratory is focused on adapting findings of basic developmental and stem cell biology to translational cardiovascular medicine. Read more about Ibrahim Domian, MD, PhD
Massachusetts General Hospital Harvard Medical School
The Pediatric Surgical Research Laboratories focus on Developmental Biology, some areas of which hold promise for clinical application to benefit both pediatric and adult patients. Read more about Patricia K. Donahoe, MD
The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification, differentiation, and migration paths taken by specific sets of cells originating from primitive neuroectoderm. Read more about Susan Dymecki, MD, PhD
Brigham and Women's Hospital Harvard Medical School
The primary focus of the Ebert laboratory is the biology and treatment of clonal hematopoiesis and myeloid malignancies. Our genetic studies have led to the characterization of clonal hematopoiesis of indeterminate potential (CHIP) and the identification of mutations in MDS that predict overall survival, outcome following bone marrow transplantation, Read more about Benjamin Ebert, MD, PhD
Brigham and Women's Hospital Dana-Farber Cancer Institute Harvard Medical School
Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth. Read more about Wolfram Goessling, MD, PhD
