Co-lead of HSCI's Nervous System Diseases Program Paola Arlotta and postdoctoral fellow Giorgia Quadrato have produced long-cultured brain organoids that have the potential to advance our understanding of brain development
SMN protein (red) is necessary for the survival of spinal cord neurons (motor neurons) responsible for breathing and all movement. Harvard researchers have found a compound that stabilized this protein in mouse and human motor neurons. This may lead to the development of new treatments for
Young neurons (pink), responsible for encoding new memories, must compete with mature neurons (green) to survive and integrate into the hippocampal circuit. Photo courtesy of Kathleen McAvoy, Sahay Lab.
In the spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid tissue and
Despite scar tissue (blue), axons were able to regenerate (white) after axon injury. HSCI researchers show axons form functional synaptic connections with their target, but unexpectedly, exhibit conduction defect due to lack of myelination. Combining regeneration