Aging Research Group

Two resilient dogs point to new targets for Duchenne muscular dystrophy

May 22, 2017

Adapted from a Boston Children's Hospital press release

Two golden retrievers that had the genetic mutation for Duchenne muscular dystrophy (DMD), yet remained healthy, have offered up yet another lead for treating this muscle-wasting disorder.

For several years, Natássia Vieira, PhD, of the University of São Paolo, also a fellow in the Boston Children’s Hospital lab of HSCI Principal Faculty  Read more about Two resilient dogs point to new targets for Duchenne muscular dystrophy

Targeted BMI1 inhibition impairs tumor growth lung adenocarcinomas with low CEBPα Expression

August 3, 2016

Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), in collaboration with Harvard Stem Cell Institute (HSCI), have discovered a new way in which the development of lung cancer can be stopped. In a study published in Science Translational Medicine, the researchers found that inhibiting a protein called BMI1 impaired tumour growth in lung cancer.

The study was led by HSCI Principal Faculty member Daniel Tenen, MD, his associate Elena Levantini, PhD, and included first author Dr Kol Jia Yong, a former CSI Read more about Targeted BMI1 inhibition impairs tumor growth lung adenocarcinomas with low CEBPα Expression