Markus Frank

Restoring vision

November 26, 2019

A stem cell therapy for cornea regeneration reaches the clinical-trial stage

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By Jessica Lau

As the eye’s outer layer of protection, the cornea needs to constantly regenerate to maintain a clear surface. Losing the cornea-regenerating stem cells leads to cloudiness — like trying to see...

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Can we restore sight?

November 7, 2018

Markus Frank and his colleagues are reprogramming skin cells with the goal of giving people back their sight.

  • Seed funding from HSCI led Markus Frank and his colleagues to discover that the cell surface molecule ABCB5 can be used to identify limbal stem cells, which regenerate the cornea.
  • The team is developing ABCB5-positive cell therapy as a treatment for vision loss due to limbal stem cell deficiency.

Markus Frank, M.D., co-leader of the HSCI Skin Program, is reprogramming stem cells from the skin...

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