Study reveals zebrafish make an unexpected decision when faced with conflicting opportunities

Discovery opens doors to improving diagnostics and developing new therapy for majority of ALS patients

Summary

• HSCI-funded research using human pluripotent stem cell models and tissue from ALS patients found that the protein TDP-43 regulates a gene called Stathmin2 (STMN2).
   
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Clifford Woolf wants to reboot drug discovery to find a new way to treat pain: effectively and responsibly.

• Woolf’s goal is to stop the opioid crisis by rejecting the conventional approach to drug discovery and developing painkillers that do not harm people or communities. 
• He is using stem cells to create models of pain, outside the body and in a dish, that can be used to screen for drugs swiftly and on a large scale.
• The new approach requires ‘all hands’: expertise, equipment, and collaboration in stem...