May 29, 2019

# Potential therapeutic target for ALS

January 16, 2019

## Summary

• HSCI-funded research using human pluripotent stem cell models and tissue from ALS patients found that the protein TDP-43 regulates a gene called Stathmin2 (STMN2).

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# Reinventing painkillers

November 5, 2018

### Clifford Woolf wants to reboot drug discovery to find a new way to treat pain: effectively and responsibly.

• Woolf’s goal is to stop the opioid crisis by rejecting the conventional approach to drug discovery and developing painkillers that do not harm people or communities.
• He is using stem cells to create models of pain, outside the body and in a dish, that can be used to screen for drugs swiftly and on a large scale.
• The new approach requires ‘all hands’: expertise, equipment, and collaboration in stem...