The Melero-Martin laboratory seeks multiple highly motivated post-doctoral research fellows to investigate the mechanism by which vascular networks are formed from pluripotent stem cells and to develop novel approaches to therapeutic vascularization and tissue regeneration.
Up to four postdoctoral fellow positions are available to work on the following NIH-funded projects:
Project 1 - Vascular niche bioengineering for human bone regeneration. Goal: To elucidate the mechanisms by which blood vessels regulate the osteogenic activity of human mesenchymal stem cells and to develop new therapeutic strategies to regenerate bone.
Project 2 - Enhancing endothelial cell engraftment via transplantation of exogenous mitochondria. Goal: To dissect the mechanism by which mitochondria transfer renders cytoprotection in endothelial cells.
Project 3 - Regulation of endothelial cell specification. Goal: To dissect the activity of the transcription factor ETV2 to drive endothelial cell specification in human pluripotent stem cells.
Project 4 - Vascular networks genetically engineered for protein drug delivery. Goal: To establish the feasibility of using bioengineered drug-secreting vascular networks to treat a clotting deficiency.
All work will involve human stem cell culture, molecular biology, and mouse xenograft models.
- Ph.D., Sc.D., or equivalent degree (or soon to be completed)
- A record of innovative publications (first-authored publications in peer-reviewed journals)
- Experience with stem cell culture, molecular biology, and animal models is highly desirable
- Independent in scientific research and writing, self-motivated, and ethical
- Excellent communication and organizational skills
- Strong interest in regenerative medicine
Applicants should send a CV, a brief statement of interest, and contact information for three references to Dr. Melero-Martin (firstname.lastname@example.org). Salary will be commensurate with experience.
Boston Children's Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.