Kastanenka Lab: Postdoctoral Fellow

A post-doctoral position is available in the laboratory of Dr. Ksenia Kastanenka at Massachusetts General Hospital and Harvard Medical School. The scientific efforts of the laboratory are geared toward studies of Alzheimer’s disease. A post-doctoral fellow with extensive stem cell research experience is being recruited to start an exciting project investigating the role of MGE-derived interneurons on progression of Alzheimer’s disease using mouse models. The laboratory implements state-of-the-art technology, such as in vivo imaging with multiphoton microscopy, wide-field imaging of voltage-sensitive dyes and optogenetics. 

Responsibilities

We seek a self-motivated individual with a Ph.D. in Neuroscience or related biomedical discipline with a strong background in stem cell work and an enthusiasm for multidisciplinary research. Evidence of prior productivity is required evidenced by research publications. Good inter-personal and communication skills are a must.

The following skills are preferable, however are not required:

  • Skilled at rodent husbandry, handling, genotyping, and behavioral tests (mobility, fear conditioning, novel object recognition, etc.)
  • Animal models of Alzheimer’s disease
  • Widefield imaging
  • Multiphoton imaging
  • Optogenetics
  • Specimen and sample preparation
  • Designing and performing experiments in order to produce reliable and precise data
  • Familiarity with or expertise in immunohistochemistry, immunoblotting, and light microscopy
  • Capable to design and execute experiments
  • Prepare and present findings at conferences
  • Draft material for the preparation of manuscripts, grants, and presentations

The work will be performed in a research laboratory in the Charlestown Navy Yard campus of Massachusetts General Hospital and Harvard Medical School.

Requirements

Skills

  • Isolation, culture, differentiation and transplantation of mouse fetal MGE-derived interneurons and/or
  • Differentiation, maintenance and transplantation of human stem-cell derived MGE-like interneurons
  • Ability to work independently
  • Willingness to work well with other lab members
  • Precision and attention to detail
  • Flexibility
  • Ability to resolve technical problems and analytical skills is necessary
  • High degree of computer literacy
  • Able to quickly learn new skills and apply those skills in a fast-paced research environment

Experience

  • Must have previous experience in a research lab

Educaton

  • A PhD degree in neuroscience or related biomedical discipline is required
  • Expertise with other neurodegenerative disease is preferred
  • Strong publication record preferred
  • Excellent organizational, interpersonal, and oral and written skills are necessary

Apply

To apply, send a CV, cover letter and 3 references to Dr. Ksenia Kastanenka at kkastanenka@mgh.harvard.edu