Craft Lab: Research Scientist/Post-doctoral Fellow

Orthopedic Research Laboratories
Boston Children’s Hospital
Harvard Medical School
Harvard Stem Cell Institute

Clinical Translation of iPSC-derived cartilage

We seek the best candidate, either motivated research scientist or postdoctoral fellow, to join our stem cell and translational research team to participate in preclinical cartilage repair studies.  The position requires previous hands-on tissue engineering experience (preferably with cartilage, biomaterials, and physical analyses of constructs e.g., histology, biomechanics, biochemistry). This is a full time research position with an immediate start date available. 

The candidate will be specifically responsible for optimizing and producing cartilage implants based on the pioneering directed differentiation methods the Craft lab has developed to generate articular cartilage from hESCs/iPSCs (Craft et al., 2015 NBT, Gardner et al., 2019 eCM). The day-to-day responsibilities will primarily be in cell culture, and the candidate may learn and perform stem cell differentiations, flow cytometry, qRT-PCR, transcriptomics (bulk and single cell RNA-seq), confocal microscopy and histology. The candidate has an opportunity to play a role in large animal studies. Lab tasks shared among our group include preparation of reagents and media, bottle washing/autoclaving, and maintenance of laboratory equipment and supplies.  

Requirements

The applicant must have a minimum of a Bachelor’s degree in Biology/Biomedical science (or equivalent). Post-doctoral and Master’s candidates are welcome.  The applicant must have at least two years of mammalian cell culture experience with high priority in the cartilage tissue engineering space, and a strong understanding of molecular biology. Excellent communications skills in English are required.  Due to the precise timing of directed differentiation experiments, occasional weekend work is expected (shared among lab members). 

The position will be offered through Boston Children’s Hospital, with additional criteria that will need to be met. Salary will commensurate with experience/position title, and includes a benefits package. 

Apply

Applicants should email their CV, contact information for two academic or professional referees, and a brief cover letter describing their background to Dr. April Craft (april.craft@childrens.harvard.edu).