Research Associate II (the Stanley Center)

The goal of the Stanley Center for Psychiatric Research at the Broad Institute is to improve mental health through research. Over the last several years, the Stanley Center and the psychiatric genetics community have gained unprecedented insight into the genetic basis of schizophrenia, autism and bipolar disorder. Our focus now is to determine how the genetic findings contribute to disease mechanisms, which is essential for the identification of drug targets and eventually the development of effective treatments.

Broadly speaking, the Stem Cell team at the Stanley Center leverages human pluripotent stem cell (hPSC) biology and in vitro differentiation in order to investigate causal relationships between disease-associated genetic variants and neuronal phenotypes. This includes using patient-derived induced pluripotent stem cell (iPSC) lines as well as CRISPR/Cas9-based genome engineering technology, and we are searching for a talented and responsible stem cell biologist to support these efforts. The candidate's background must demonstrate a proven ability to work collaboratively and to contribute to high quality research projects at predetermined milestones.


* Maintain, expand and characterize of hPSCs
* Conduct gene-targeting experiments using CRISPR/Cas9
* Work closely with multidisciplinary teams to provide technical expertise and develop project specific protocols
* Troubleshoot to resolve problems and participate in new technology evaluation, development and implementation
* Document, compile, and analyze experimental data
* Attend and present at team meetings to share results, plan projects and experiments, and ensure that projects support team goals

* May perform other duties as assigned


* BS or MS in the biological sciences
* Minimum 2+ years of industrial or academic experience with mammalian cell culture
* Exceptional oral and written communication skills
* Ability to organize and manage complex projects
* Effective and highly collaborative team member
* Commitment to delivering goals at predetermined milestones
* Laboratory management experience a plus

* Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems


* Normal working conditions
The Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

Visit the Broad Institute careers site to apply. (Requisition number 1959)


See also: Job Opportunity