The Sahay Lab is looking for highly self-motivated scientists to join it’s exciting and cohesive community. Our research program is aimed at elucidating the role of adult-born hippocampal neurons in regulation of cognition and mood in adulthood and aging. As part of this endeavor we are interested (i) in the molecular and circuit-based mechanisms that govern neural stem cell homeostasis and the integration and functions of adult-born neurons, (ii) how the properties and connectivity of adult-born neurons relate to function, (iii) how encoding by adult-born neurons modulates stress and fear responses and, (iv) the neurobiology of induced human hippocampal neuronal subtypes.
Projects will involve a combination of molecular genetic and viral based manipulations of stem cells or neural circuits, synaptic tracing, in vivo optical imaging, optogenetics, human cellular reprogramming and behavioral assays.
Postdoctoral candidates must be enthusiastic about taking on new challenges and should have demonstrated research productivity, independent thinking and rigorous training in molecular, behavioral, developmental or systems neuroscience. Candidates with experience in in vivo optical imaging or cellular reprogramming are strongly encouraged to apply.
Interested candidates should send their resume/CV and 3 letters of reference to Dr. Amar Sahay (firstname.lastname@example.org).
McAvoy et al, Modulating competition dynamics in the dentate gyrus to rejuvenate aging memory circuits, Neuron, 1 September 2016, (Advance Online Publication)
Antoine Besnard and Amar Sahay. Adult hippocampal neurogenesis, fear generalization and stress. Neuropsychopharmacology, 2016
Ikrar et al, Adult neurogenesis modifies excitability of the dentate gyrus, Frontiers in Neural Circuits, 2013
Kheirbek et al, Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders, Nature Neuroscience 2012.
Sahay et al., Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature, 2011
Please visit http://www.sahaylab.com to familiarize yourself with the scope of our research program. The laboratory is supported by NIMH and NIA and private foundation funds.