We are looking for an exceptional Postdoctoral Fellow to join the Stem Cell Program at the Stanley Center for Psychiatric Research at the Broad Institute, in collaboration with the Department of Stem Cell and Regenerative Biology at Harvard University. Broadly speaking, our team generates human brain cell types from pluripotent stem cells (hPSCs) in vitro, in order to investigate causal relationships between psychiatric disease-associated genetic variants and neuronal phenotypes.
The Postdoctoral Fellow will work with Dr. Lindy Barrett (Broad Institute) in collaboration with Dr. Kevin Eggan's laboratory (Harvard University) to lead a study on mechanisms of RNA binding proteins in human neurons. A broad body of literature implicates RNA binding proteins either directly or indirectly in Autism, Schizophrenia and Intellectual Disability but the mechanisms by which they produce dysfunction, and the convergence of these mechanisms across neurodevelopmental disorders have not been fully elucidated. Specifically, the candidate will generate cortical neurons from hPSCs in vitro, employ technologies such as CRISPR/Cas9-based genome engineering and CLIP-Sequencing and perform detailed mechanistic follow-up to elucidate mechanisms of RNA binding proteins in normal neurobiology and disease. The ideal candidate will be detail oriented, creative and comfortable working both independently as well as in a highly collaborative environment. Research activities will take place at both the Broad Institute and Harvard University.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
-Actively participate at interdepartmental seminars and meetings to discuss project plans, present data and provide technical expertise
REQUIREMENTS
-Willingness and drive to lead project development
WORKING CONDITIONS
EOE / Minorities / Females / Protected Veterans / Disabilities