Postdoctoral Fellow (Barrett Lab)

We are looking for an exceptional Postdoctoral Associate to join Dr. Lindy Barrett's laboratory in the Stem Cell Program at the Stanley Center for Psychiatric Research at the Broad Institute, in collaboration with the Department of Stem Cell and Regenerative Biology at Harvard University. 

Recent advances in human pluripotent stem cell (hPSC) biology and in vitro differentiation now allow for the generation of multiple human brain cell types in a dish. However, as with most in vitroderived cell types, human neurons remain relatively immature, more closely resembling embryonic as opposed to adult brain cells. This poses major challenges for mechanistic studies as well as disease modeling and therapeutic discovery. We are looking for a highly motivated Postdoctoral Associate to work on a funded project investigating mechanisms of synaptogenesis using in vitroderived human cortical neurons. In collaboration with Dr. Lee Rubin's laboratory, the candidate will identify pathways that modulate synapse formation using a small-scale screening approach, and perform in depth molecular and functional analyses of putative hits to understand how they impact neuronal development. The ideal candidate will be detail oriented, creative and comfortable working both independently as well as in a highly collaborative research environment. Research activities will take place at both the Broad Institute and Harvard University.

-Perform hPSC culture, in vitro differentiation and synaptic assay development
-Perform small-scale collaborative screen to probe the impact of candidate pathways on synapse formation
-Conduct detailed molecular and functional analyses of putative hits
-Work both independently and collaboratively to expand technical capabilities and identify new research avenues

-Actively participate at cross-institutional seminars and meetings at Harvard University and the Broad Institute to discuss project plans and present data


-Ph.D. in Neurobiology, Cell Biology, Bioengineering or related field
-Maximum 0-2 years of relevant postdoctoral experience
-Expertise in developmental neurobiology strongly preferred
-Experience with neuronal cell culture strongly preferred
-Strong publication record and exceptional oral and written communication skills
-Ability to organize and manage complex projects in a fast-paced environment

-Willingness and drive to lead project development.



-Normal working conditions


EOE / Minorities / Females / Protected Veterans / Disabilities