Nervous System Diseases

Paola Arlotta, PhD

Paola Arlotta, PhD

Harvard Department of Stem Cell and Regenerative Biology

Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex

The execution of critical behaviors like movement, emotion, and intelligence relies on the orchestrated integration into functional circuits of an outstanding diversity of neuronal subtypes. Focusing on excitatory pyramidal neurons of the mammalian cerebral cortex, our work aims to understand the

Susan Dymecki, MD, PhD

Susan Dymecki, MD, PhD

Harvard Medical School

The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification, differentiation, and migration paths taken by specific sets of cells originating from primitive neuroectoderm.