Boston Children's Hospital

Suneet Agarwal, MD, PhD

Suneet Agarwal, MD, PhD

Boston Children's Hospital

Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system.  We would like to study these genetic blood disorders by “turning back the clock” – using new technology in stem cell biology to take skin cells from patients with genetic blood disorders and return them to an embryonic-like state, wherein they regain the ability to form any type of cell in the body. 

David Breault, MD, PhD

David Breault, MD, PhD

Boston Children's Hospital

Dr. David Breault's research has exploited the fact the mouse telomerase (mTert) is a biomarker for embryonic and tissue stem cells. He has developed a streamlined technique for isolating and characterizing adult stem cells from a variety of tissues using genetically engineered reporter mice.

Alan Cantor, MD, PhD

Alan Cantor, MD, PhD

Boston Children's Hospital

Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain inherited platelet disorders and hematologic malignancies.

George Q. Daley, MD, PhD

George Q. Daley, MD, PhD

Boston Children's Hospital
Harvard Medical School
Howard Hughes Medical Institute

George Q. Daley, M.D., Ph.D, seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells (cited as a “Top Ten Breakthrough” by Science magazine in 2003), and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the “Breakthrough of the Year” issue of Science magazine in 2008). 

Zhigang He, PhD, BM

Zhigang He, PhD, BM

Harvard Medical School
Boston Children's Hospital
Dana-Farber Cancer Institute

Developing neural repair strategies to restore functions after central nervous system (CNS) injury such as spinal cord injury is still an unmet challenge.

Stuart Orkin, MD

Stuart Orkin, MD

Dana-Farber Cancer Institute
Boston Children's Hospital
Howard Hughes Medical Institute

The laboratory utilizes multidisciplinary approaches to understand how mammalian cells choose specific fates and how mutations in important transcriptional regulators lead to developmental defects or malignancy.

William T. Pu, MD

William T. Pu, MD

Boston Children's Hospital
Harvard Medical School

Goals of Dr. Pu's research include:
1. To understand the transcriptional network regulating heart development and disease
2. To understand cell lineage specification in heart development and regeneration
3. To understand genetic contributions to congenital heart disease.

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